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CDC empiric definition for CFS from 2005 Author: Kasper Ezelius, M.Sc., Örebro, Sweden, Northern Europe, http://me-cfs.se Date: September 28, 2009 Contents: CDC
empiric definition 2005 - Protest against CDC using it CDC empiric CFS definition 2005 - Flaws in scientific
approach Suggestions for future Research Earlier documents of the same matter CDC empiric definition 2005 - Protest against CDC using itKnowing
that the petition against the CDC uses the CFS-Reeves-2005 definition has
been available since April 15, 2009, I am surprised that only around 1.700
have signed so far. The response from the international ME-community is lame.
I would have expected around 17.000-170.000 instead of the few 1.700 signatures,
knowing the worldwide number of people with ME. The petition text is simple
"CDC CFS research should not involve the empirical definition
(2005)", and I think nobody with ME could ever object to that. I wonder
where all the US inhabitants with ME are? Why do so few sign? They should be
very large in number - around a million. I think
the petition is important, and will be like a "burial stone" for
lost research into ME. A historical document how CDC changed its course, and
how the whole world cried out loud. A remainder for future generations of ME
patients, to know that their predecessors really did protest against the
"burial" of CDC sponsored biomedical research into ME. I hope the
petition will stay on the web for ever in order to be a monument over lost
voices, and lost hope for patients worldwide hoping for a cure from their
prison of invalidity in their life-time. Sign at
the bottom of the page of the petition, then push the buttom "Sing
petition". You are then taken to a new page with a text at the top that
the signature was sucessfully registrered. On the same page you are urged to
donate money to the site, but you can simply ignore that. Your signature will
be registred anyhow. Only
sign once! Sign Tom
Kindlons petition "CDC CFS
research should not involve the empirical definition (2005)" here: CDC empiric CFS definition 2005 - Flaws in scientific approachI have
thought about how I would like to describe the flaws of the Reeves
methodology, with statistics, math and reasoning, but I do not have the
energy, but I will make a short summary below. I would
have thought that the scientific way to go, would be to create distributions
in a multidimensional space of ME people in one set and the general
population (healthy and sick, except ME) in the other set. Then I would have
tried to create the largest distance for the points the multidimensional set
of ME-people to the points in the set of the general population, in order to
try to separate the two sets by a multidimensional plane. The location of the
plane should be adjusted for the highest sensitivity and specificity. I would
have included physiological parameters and biomedical markers in a large
amount in the multidimensional analysis, because ME is a physiological
disease. I would also have tried to include more signs instead of only having
symptoms. Although,
I am not sure I would ever have used the multidimensional approach for
defining ME. Finally, it is what we put in the set of ME patients (for the
multidimensional study) that defines the disease. Therefore, one can simply
use the original definition for ME to define what is ME. Why go cross the
river to get water? I would
have required post-exertional malaise to be present in a ME/CFS-definition.
Post-exertional malaise should be present as a symptom, but also measured by
objective test. The research is more and more showing a clear picture that
post-exertional malaise lasting for 1-3 days, or more, is measurable by brain
scans of blood flow, blood parameters (oxidative stress, ion channels,
adrenergic receptors and immune molecules), and oxygen uptake for repeated
exercise test. I think that a patient without post-exertional malaise, has a
different pathophysiology and should be excluded from the ME-set. I also
think that mental fog, that usually increases with upright posture, is a
hallmark symptom. What
Reeves has done is to summarize a multidimensional space into ONE variable.
This one-dimensional space is in simplified terms the sum of psychological
and subjective symptoms. This means that an indefinite number of combinations
of symptoms may score enough to be positive for CFS-Reeves-2005 (more
appropriately labelled as "Reeves Illness Melange"), so one can
expect that a multitude of symptom clusters exist in the mix of
CFS-Reeves-2005. No clear picture of symptoms can be distinguished. It is
such a big insult to scientific and logical thinking, that I can not believe
that one of the worlds largest and most important agency, CDC, can be the
part of it. If a
change of the CFS definition is made, it shall never be made over one night.
One should use the new criteria in parallel with the old criteria during
several years in order to keep comparability with research made with the old
definition, and in order to validate the new definition. At this time the
Canada-definition [1] is the most interesting candidate of replacing
CFS-Fukuda in ME/CFS research. CFS-Fukuda does not require mandatory ME/CFS
symptoms as for example post-exertional malaise lasting 1-3 days or more, it
does not require mental fog. CFS-Fukuda is perceived as very vague by ME/CFS
patients, while CFS-Canada-2003, is perceived as a very good description of
their condition and something they can relate to. Note: I
would have spared the extensive multidimensional approach to try to find
clusters and sub-groups within the ME-cohort. Suggestions for future ResearchI hope the scientific
world will continue to study abnormalities in ME patients during
post-exertional malaise. Many tests have been in the normal range, while one
studied ME patients in in a state of rest, but when one studies what happens
after exertion one really begins to discover that there are indeed
abnormalities. The abonormalities are discovered in the dynamic response to
exertion. I think this is the way to go. Scientists are discovering things
that never has crossed their mind to test for several years. Biomedical and
physiological findings are consistent with the patients reports of feeling
awful after exertion. This direction of research should be continued and be
extended into new areas of physiological and biomedical tests. Because of the
hijacking of the term CFS by Reeves and CDC, by replacing the already vague
definition of CFS-Fukuda with the pot-pourri of CFS-Reeves, I think it is
important for the scientitsts that use CFS-Fukuda to describe what kind of
definition that has been used in the title of the scientific articles,
otherwise things will start to be mixed up. I have no really good suggestion
in how to do that. Maybe by referring to "CFS - Fukuda definition"
in the title, while "chronic fatigue syndrome according to the Fukuda
definition" will very long. If the Canadian definition is used one can
maybe refer to "ME/CFS-Canada-2003" or "patients with ME/CFS
according to the Canadian definition from 2003" in the title. The
general reader will never understand that different definitions have been
used unless it is clearly stated, and they will assume that all articles with
"chronic fatigue syndrome" studies the same kind of patients, and
this can make huge harm to the progress in scientific research into ME. Hopefully more and more
scientists will start to Use CFS-Fukuda and ME/CFS-Canada-2003 in paralell.
The international biomedical research fund of "ME-föreningen" in
Sweden requires so, and I hope more charities and research funds will start
to do the same. References
[1] Carruthers BM, Jain AK, De Meirleir KL, et al. Myalgic
encephalomyelitis/chronic fatigue syndrome: clinical working case definition,
diagnostic and treatment protocols. Journal of Chronic Fatigue Syndrome 2003;11:7–36. http://www.mefmaction.net/documents/journal.pdf [2] Fukuda K, Straus SE, Hickie I, Sharpe MC,
Dobbins JG, Komaroff A. The chronic fatigue
syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern
Med. 1994;121:953-959. http://www.annals.org/cgi/reprint/121/12/953.pdf [3] Reeves WC, et al. Chronic fatigue
syndrome--a clinically empirical approach to its definition and study. BMC Med. 2005
Dec 15;3:19. Earlier documents of the same matterIn chronologic order Use the Canadian criteria 2003 for CFS in the USA. Kasper Ezelius. June 22, 2008: 080622-Use-Canada-criteria-in-USA.pdf Letter to the President and Congress of the United States of America, U.S. Department of Health and Human Services, U.S. National Institutes of Health, and U.S. Centers for Disease Control. Resolution in order to make cohorts less heterogeneous. Kasper Ezelius. 1st of September 2008: http://me-cfs.se/dok/080901-mod-cfs.pdf Research into CFS (Chronic Fatigue Syndrome) and ME (Myalgic Encephalomyelitis) has been blurred through many decades due to heterogeneous patient populations (cohorts). One problem is that researchers, as well as clinicians, have different interpretations of what is CFS. Some researchers/clinicians would (incorrectly) not set a CDC CFS diagnosis if post-exertional malaise is not present, although the CDC CFS definition does not require post-exertional malaise. How to categorize ME and CFS. Kasper Ezelius. 23 October 2008: http://me-cfs.se/dok/081023-categorize.pdf This document is a brief sketch for further discussion on how to proceed with taxonomy in research related to Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). CFS is no longer CFS, and it was never ME. Kasper Ezelius. 5
December 2008: http://me-cfs.se/dok/081205-cfs-no-longer-cfs.pdf The Centres for Disease Control and Prevention in the USA has adopted a more including criterion for chronic fatigue syndrome which is important to be aware of when reading scientific papers. It is important to know that the new criteria is so much "loosened up" that it encompasses 2,5% of the general population instead of around 0,4% as with the earlier criteria. How to stratify and group patients in future research is proposed. The use of disjoint sets of patients is encouraged. Copyright: ©Kasper Ezelius 2009 The text may be cited in whole or in part, if the author and title are
mentioned, as well as a link to the original document. |