Myalgisk Encefalomyelit - Referenser

 

Referenslista

 

ME/CFS information: http://me-cfs.se

Kanadas koncensusrapport "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (Carruthers et al, ISBN 0-7890-2207-9, år 2003) finns i "Journal of Chronic Fatigue Syndrome", http://www.mefmaction.net/documents/journal.pdf

Södra Australiens handledning: "ME/CFS Guidelines - Myalgic Encephalopathy (ME)/Chronic Fatigue Syndrome (CFS) - Management Guidelines for General Practitioners", ISBN 0 7308 9334 0, år 2004, http://www.co-cure.org/AU_CFS.pdf

Bok: Pedriatric Chronic Fatigue Syndrome, Kenny De Meirleir et al, 2006/2007, The Haworth Press, http://www.haworthpress.com

Bok: Chronic Fatigue Syndrome - A Biological Approach, Patrick Englebienne et al, 2002, CRC Press, ISBN 0-8493-1046-6, http://www.crcpress.com

Bok: Enteroviral and toxin mediated myalgic encephalomyelitis/chronic fatigue syndrome and other organ pathologies, John Richardson, 2001, Haworth Medical Press, ISBN 0-7890-1127.

Bok: Chronic Fatigue Syndrome, Genes, and Infection, The Eta-1/Op paradigm, Roberto Patarca Montero, Haworth Press 2003.

Bok: The clinical and scientific basis of myalgic encephalomyelitis chronic fatigue syndrome, Byron Hyde, 1992, The Nightinggale Research Foundation (http://www.nightingale.ca).

DVD kit: ME konferensen i London i maj 2006, http://www.investinme.org/IIME%20Campaigning-MEConference%20Review.htm

DVD kit: Endags föreläsning för läkare av Dr. Meirleir, http://www.mefmaction.net/default.aspx?page=demeirleirpatients, Observera att det är NTSC kodning. Fungerar på dator men TVn måste klara NTSC standard.

Tidskrift: Journal of Chronic Fatigue Syndrome, http://www.haworthpress.com/web/JCFS

A New Clinical Entity?, The Lancet, London, Lördag den 26 maj 1956, sid 789-190, http://www.meresearch.org.uk/information/keypubs/Lancet%201956.pdf

Sophia Mirza i England, dog som resultat av ME, http://www.investinme.org/index.html,  http://www.investinme.org/Mediatelevision2.htm

R.E.D. Laboratories N.V., Z.1, Researchpark 100, B-1731 Zellik, Belgien, Phone: +32 (0)2 481 53 24, Fax: +32 (0)2 481 53 11, http://www.redlaboratories.be/2/index.php

ME/CFS: A Clinical Case Definition and Guidelines for Medical Practitioners - An overview of the Canadian Consensus Document
Carrthers et al, 2005, ISBN 0-7890-227-9, Haworth Medical Press Inc.,
http://www.mefmaction.net/documents/me_overview.pdf

Norskt TV inslag om svår ME, TV program NRK puls, familj Krisner, http://www.investinme.org/Mediatelevision3.htm

 

 

 

Information om forskning kring ME från organisationer

 

Invest in ME

Research News

http://www.investinme.org/ResearchCurrentProjects.htm

 

ME Research UK

Gene Research: A Scientific 'Signature' for ME/CFS?

http://www.meresearch.org.uk/research/projects/genesig.html

 

CFS & FM Support Group of DFW (Dallas Forth Worth) (http://www.dfwcfids.org/index.shtml) ger ut ett nyhetsbrev (http://www.dfwcfids.org/archive/newsletter.pdf) som innehåller en massa intressant information. Två nummer från 1995 (http://www.dfwcfids.org/archive/index.html) innehåller mycket om Cheneys teorier om hjärta hos ME drabbade. Det står om oxidativ påverkan i celler och hur det kan motverkas. Det skall numera också att gå att köpa DVDs med Cheneys föredrag.

 

Phoenix Rise har en bra samling med information om ME: http://www.phoenix-cfs.org/The%20SITE/mainmenu.htm . Prenumerera på nyhetsbrevet som innehåller sammandrag om forskning om ME varje månad: http://www.phoenix-cfs.org/Phoenix%20Rising%20subscribe.htm

 

MEsite - en Dansk hemsida - skriver om historian bakom termerna ME och CFS: http://www.mesite.dk/ME-CFShistory.htm

 

 

 

Information om forskning kring ME från media

 

BBC Saturday,

28 May, 2005

Scientists 'unlock ME genetics'

http://news.bbc.co.uk/1/hi/health/4580051.stm

 

NewScientist

21 July 2005

Chronic fatigue is not all in the mind

http://www.newscientist.com/article.ns?id=mg18725093.700

 

Evening Times

2005-05-05

Research into ME hit by cash crisis

http://www.eveningtimes.co.uk/hi/news/5039240.html

 

Scotsman

20-May-05

Scottish scientists find 'key to curing ME'

http://news.scotsman.com/scotland.cfm?id=550752005

 

 

 

Vetenskapliga tidskifter

 

En ny molekyl funnen som är har en nyckelroll i smärtkänslighet:

http://www.sciencedaily.com/releases/2006/10/061023092055.htm

 

 

 

Referenser till forskningsartiklar relaterad till ME

 

Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome)

Basant K Puri

J Clin Pathol. Accepted 31 July 2006

http://jcp.bmjjournals.com/cgi/content/abstract/jcp.2006.042424v1

 

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability.

Maes M, Mihaylova I, Leunis JC.  

J Affect Disord. 2006 Sep 26;

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17007934&query_hl=5&itool=pubmed_docsum

 

Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms.

Nicolson GL, Gan R, Haier J.

APMIS. 2003 May;111(5):557-66.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12887507&query_hl=7&itool=pubmed_docsum

 

Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS).
Snell CR, Vanness JM, Strayer DR, Stevens SR.

In Vivo. 2005 Mar-Apr;19(2):387-90.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15796202&query_hl=6&itool=pubmed_docsum

 

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Maes M, Mihaylova I, De Ruyter M.

J Affect Disord. 2006 Feb;90(2-3):141-7. Epub 2005 Dec 9.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16338007&query_hl=6&itool=pubmed_docsum

 

Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms.

Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ. 

Free Radic Biol Med. 2005 Sep 1;39(5):584-9.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16085177&query_hl=1&itool=pubmed_docsum

 

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise.

Jammes Y, Steinberg JG, Mambrini O, Bregeon F, Delliaux S.

J Intern Med. 2005 Mar;257(3):299-310.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15715687&query_hl=6&itool=pubmed_docsum

 

Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome.

Vecchiet J, Cipollone F, Falasca K, Mezzetti A, Pizzigallo E, Bucciarelli T, De Laurentis S, Affaitati G, De Cesare D, Giamberardino MA.

Neurosci Lett. 2003 Jan 2;335(3):151-4.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12531455&query_hl=6&itool=pubmed_docsum

 

Long-term efficacy of cognitive-behavioral therapy by general practitioners for fatigue: A 4-year follow-up study.

J Psychosom Res. 2006 Nov;61(5):601-7.

Leone SS, Huibers MJ, Kant I, van Amelsvoort LG, van Schayck CP,

Bleijenberg G, Knottnerus JA.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17084137&query_hl=1&itool=pubmed_docsum

 

http://www.elsevier.com/wps/find/journaldescription.cws_home/525474/description#description

 

http://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind0611A&L=CO-CURE&P=R7452&I=-3

 

The role of enterovirus in chronic fatigue syndrome.

Chia JK.

J Clin Pathol. 2005 Nov;58(11):1126-32.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16254097&query_hl=2&itool=pubmed_docsum

 

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

Lundell K, Qazi S, Eddy L, Uckun FM.

Arzneimittelforschung. 2006;56(6):399-404.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16889122&query_hl=5&itool=pubmed_docsum

 

Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis [Article in Chinese]

Li YJ, Wang DX, Zhang FM, Liu ZD, Yang AY, Ykuta K.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Dec;17(4):330-3.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15340544&query_hl=5&itool=pubmed_DocSum

 

Increased neutrophil apoptosis in chronic fatigue syndrome.

Kennedy G, Spence V, Underwood C, Belch JJ.

J Clin Pathol. 2004 Aug;57(8):891-3

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15280416&query_hl=5&itool=pubmed_DocSum

 

Influenza vaccination: is it appropriate in chronic fatigue syndrome?

Sleigh KM, Marra FH, Stiver HG.

Am J Respir Med. 2002;1(1):3-9.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14720070&query_hl=5&itool=pubmed_DocSum

 

Diagnostic evaluation of 2', 5'-oligoadenylate synthetase activities and antibodies against Epstein-Barr virus and Coxiella burnetii in patients with chronic fatigue syndrome in Japan.

Ikuta K, Yamada T, Shimomura T, Kuratsune H, Kawahara R, Ikawa S, Ohnishi E, Sokawa Y, Fukushi H, Hirai K, Watanabe Y, Kurata T, Kitani T, Sairenji T.

Microbes Infect. 2003 Oct;5(12):1096-102.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14554250&query_hl=5&itool=pubmed_DocSum

 

Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms.

Nicolson GL, Gan R, Haier J.

APMIS. 2003 May;111(5):557-66.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12887507&query_hl=5&itool=pubmed_DocSum

 

Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes.

Endresen GK.

Department of Rheumatology, University of Oslo, Norway.

Rheumatol Int. 2003 Sep;23(5):211-5. Epub 2003 Jul 16.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12879275&query_hl=5&itool=pubmed_DocSum

 

RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.

Tiev KP, Demettre E, Ercolano P, Bastide L, Lebleu B, Cabane J.

Service de Medecine Interne, Hopital Saint Antoine, Paris, France.

Clin Diagn Lab Immunol. 2003 Mar;10(2):315-6.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12626460&query_hl=5&itool=pubmed_DocSum

 

A six-month trial of valacyclovir in the Epstein-Barr virus subset of chronic fatigue syndrome: improvement in left ventricular function.

Lerner AM, Beqaj SH, Deeter RG, Dworkin HJ, Zervos M, Chang CH, Fitzgerald JT, Goldstein J, O'Neill W.

School of Medicine, Wayne State University, Detroit, USA.

Drugs Today (Barc). 2002 Aug;38(8):549-61.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12582420&query_hl=5&itool=pubmed_DocSum

 

High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients.

Nijs J, Nicolson GL, De Becker P, Coomans D, De Meirleir K.

Department of Human Physiology, Vrije Universiteit Brussel, Belgium.

FEMS Immunol Med Microbiol. 2002 Nov 15;34(3):209-14.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12423773&query_hl=5&itool=pubmed_DocSum

 

 

 

John Gow

 

John Gow och Abhijit Chaudhuri i England har tagit/sökt patent på en behandlingsmetod för ME 2006-08-10, http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006082390&F=0&QPN=WO2006082390

 

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome.

Chaudhuri A, Condon BR, Gow JW, Brennan D, Hadley DM.

Neuroreport. 2003 Feb 10;14(2):225-8

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12598734&query_hl=12&itool=pubmed_docsum

 

Antiviral pathway activation in patients with chronic fatigue syndrome and acute infection.

Gow JW, Simpson K, Behan PO, Chaudhuri A, McKay IC, Behan WM.

Clin Infect Dis. 2001 Dec 15;33(12):2080-1. Epub 2001 Nov 6.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11698994&query_hl=11&itool=pubmed_docsum

 

Studies on enterovirus in patients with chronic fatigue syndrome.

Gow JW, Behan WM, Simpson K, McGarry F, Keir S, Behan PO.

Clin Infect Dis. 1994 Jan;18 Suppl 1:S126-9.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8148439&query_hl=11&itool=pubmed_docsum

 

 

 

Kenny De Meirleir - RNase L forskning

 

Kenny De Meirleir, från Belgien, är en av världens främsta forskare kring ME. Har har speciellt forskat på RNase L proteinet som är
dysfunktionellt hos ME drabbade. Dr. De Meirleir är forskare och professor i Fysiologi och Intern medicin på Free University of Brussels i Belgien.

 

Prof. Dr. De Meirleir

Himmunitas

De Tyraslaan 111

B-1120  Neder-Over-Heenbeek

Belgien

phone : +32-2-266-8740

fax: +32-2-266-8750

 

http://www.immunesupport.com/library/showarticle.cfm?id=7245

De Meirleir har gjort en powerpointpresentation om ME. http://www.redlabsusa.com/slideshow.ppt

 

High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients.

Nijs J, Nicolson GL, De Becker P, Coomans D, De Meirleir K.

FEMS Immunol Med Microbiol. 2002 Nov 15;34(3):209-14.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12423773&query_hl=7&itool=pubmed_docsum

 

Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome

Nijs J, De Meirleir K.

In Vivo. 2005 Nov-Dec;19(6):1013-21

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16277015&query_hl=9&itool=pubmed_docsum

 

Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review

Mira Meeus, Jo Nijs and Kenny De Meirleir

European Journal of Pain 2006

http://www.sciencedirect.com/science/journal/10903801

 

 

RED laboratories - RNase L testet

 

RED laboratories, i Belgien, erbjuder RNase L testet som är positivt på 95% av de ME drabbade:

 

R.E.D. Laboratories N.V.

Z.1, Researchpark 100, B-1731 Zellik - Belgium

Phone: +32 (0)2 481 53 24

Fax:      +32 (0)2 481 53 11

http://www.redlaboratories.be/2/index.php?nummer=31

 

Det går att göra diagnos av ME via blodanalys med relativt stor säkerhet med hjälp av ett screening test (FASTest, Fragmented Actin Serum Test) och ett konfirmatoriskt test (RNase L). Proverna görs av RED laboratories. Se länkar nedan för information.

 

Detection of Actin Fragments in Serum: A Rapid Screening Test to Aid in the Diagnosis of Chronic Fatigue Syndrom. http://www.redlaboratories.be/2/printer.php?nummer=1&tabel=testen

 

Quantitative Measurement of RNase L Proteins: The Confirmatory Test to Aid
in the Diagnosis of Chronic Fatigue Syndrome
http://www.redlaboratories.be/2/printer.php?nummer=2&tabel=testen

 

Detection of Mycoplasma Infection. Using the Polymerase Chain Reaction (PCR) Technique http://www.redlaboratories.be/2/printer.php?nummer=3&tabel=testen

 

 

 

Jonathan Kerr - mRNA forskning

 

Dr. Jonathan Kerr i England har hittat 16 avvikelser hos halter av mRNA (messenger RNA) hos ME patienter. Dessa avvikelser relaterar till immuno, neurologiska, mitokondrie, apotosis och peroxisome. Dr. Kerr är väldigt optimistisk och hoppas kunna ta fram ett diagnostiskt test. Han tror även det finns möjlighet att hitta ett sätt att bota/lindra ME patienter. Hans första försök på läkemedel är Interferon-beta.

http://www.investinme.org/ResearchCurrentProjects.htm

http://jcp.bmjjournals.com/cgi/content/abstract/58/8/826

 

Genuttrycksstudierna av Jonathan Kerr i England

 

Messenger RNA (mRNA) har studerats hos ME drabbade. mRNa bildas genom avkodning av DNA i cellerna. mRNA "talar om" hur mycket av ett visst protein som skall produceras. Proteinerna som produceras inverkar på cellens metabolism och funktion.

 

CFS Research Foundation - England - Newsletter No 10 - Gene Expression studies - Jonathan Kerr: http://www.cfsrf.com/pdf/Newsletter-10.pdf

CFS Research Fondation - England - Curent Research: http://www.cfsrf.com/research-current.htm

CFS Research Fondation - England - Research Publications: http://www.cfsrf.com/Publications.htm

CFS Research Foundation - England - Welcome Internet Page: http://www.cfsrf.com/index.html

 

Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome

N Kaushik, D Fear, S C M Richards, C R McDermott, E F Nuwaysir, P Kellam, T J Harrison, R J Wilkinson, D A J Tyrrell, S T Holgate, J R Kerr.

Journal of Clinical Pathology 2005;58:826-832

http://jcp.bmjjournals.com/cgi/content/abstract/58/8/826

 

Current research priorities in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME): disease mechanisms, a diagnostic test and specific treatments

Kerr JR, Christian P, Hodgetts A, Langford PR, Devanur LD, Petty R, Burke B, Sinclair LI, Richards SC, Montgomery J, McDermott C, Harrison TJ, Kellam P, Nutt DJ, Holgate ST.

J Clin Pathol. 2006 Aug 25

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16935968&query_hl=1&itool=pubmed_docsum

 

Chronic fatigue syndrome

Devanur LD, Kerr JR.

J Clin Virol. 2006 Sep 13

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16978917&query_hl=3&itool=pubmed_docsum

 

 

 

Gottfrieskliniken

 

Gottfrieskliniken är specialicerad på ME och fibromyalgipatienter. De gör diagnos samt har forskning kring ett vaccin för att lindra ME symtomen:

 

Gottfries Clinic AB

Krokslätts torg 5

431 37 Mölndal

tfn 031 343 23 97

fax031 20 99 38

Läkare: Carl-Gerhard Gottfries , Björn Regland, Olof Zachrisson

 

 

Treatment with staphylococcus toxoid in fibromyalgia/chronic fatigue syndrome—a randomised controlled trial

Olof Zachrisson, Björn Regland, Marianne Jahreskog, Michael Jonsson, Margareta Kron and Carl-Gerhard Gottfries

European Journal of Pain Volume 6, Issue 6, December 2002, Pages 455-466

http://www.sciencedirect.com/science/journal/10903801

 

 

 

Övrigt

 

International Meeting on "Chlamydia and Mycoplasma Infections in humans" i Ferrara Italien http://mycoplasmas.cvm.iastate.edu/IOM/ferrara.html