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Startat av affa, 2009-02-25, 13:57
CitatVitamin D is an important regulator. It is produced not only by the UV-irradiated dermis, but also by activated macrophages, the hypercalcemia associated with sarcoidosis being attributable to production of the vitamin by macrophages in the active granulomas. The vitamin is a potent inhibitor of T-cell proliferation and of Th1 cytokine production.
CitatSarcoidosis is a disease of unknown etiology affecting lymphoid tissue and involving the formation of chronic granulomas. A chronic inflammatory Th1 response to an infectious, environmental antigen is thought to be responsible.