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Forskningsmedel för forskning kring ME

Startat av Mayordomo, 2010-01-03, 16:00

Föregående ämne - Nästa ämne


I Newcastles Universitet söks en person som kan ta fram intracellulära nanosensorer för att studera muskulära bioenergiska avvikelser vid ME.

Development of Intracellular Nanosensors to Investigate Muscle Bioenergetic Abnormalities Potentially Associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

CitatDept/School Faculty of Medical Sciences Graduate School, Newcastle University  
Project Supervisor(s) Dr P Manning
Funding Availability Directly Funded Project (European/UK Students Only)
Pyruvate dehydrogenase complex (PDC) plays a key role in the regulation of cellular energetics. Decreased function of PDC results in increased metabolism of pyruvate via the lactate dehydrogenase pathway, with subsequent overproduction of lactic acid. Impaired energy generation by muscle, an increase in the lactate/pyruvate ratio in ME/CFS, and a propensity towards excess intra-muscular acidosis following limited exercise suggests PDC dysfunction in muscles of ME/CFS patients, with implications for the mechanism of expression of fatigue.
Such sensors will include, but not be limited to, key analytes such as pyruvate, lactic acid, pH and ATP. Further, surface modification of the nanosensor will facilitate the site selective positioning of nanosensors within the cell, thus enabling organelle-directed measurements of metabolite flux in real time.
Person Specification
You should have, or expect to achieve, a first-class or upper-second-class Honours degree in a subject related to biomedical sciences


Forskarlag från hela världen är inbjudna till att ansöka medel för att avsluta en studie med tomografi av hjärna.

Se följande meddelande på Co-Cure, samt information av ME Research UK om deras vilja att finansiera en studie.

RES, MED: Update on London Neuroimaging Study
Merge, Co-Cure, 19 Jan 2010
CitatFor this reason, the two charities remain committed to funding good projects using state-of-the-art MRI technologies, and encourage established research groups across the world to apply for funding.

Structural and functional neuroimaging in ME/CFS ME Research UK http://www.meresearch.org.uk/information/publications/neuroimage.html

Ett par extra referenser nedan.

Chen R, et al.. Chronic Fatigue Syndrome and the Central Nervous System. 2008, The Journal of International Mecidal Research, 2008; 36: 867 - 874. http://www.jimronline.net/content/full/2008/87/1009.pdf

Mathew SJ, et al.. Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR Biomed. 2008 Oct 21. http://www.ncbi.nlm.nih.gov/sites/entrez/18942064