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Startat av Mayordomo, 2010-01-03, 16:00
CitatDept/School Faculty of Medical Sciences Graduate School, Newcastle University Project Supervisor(s) Dr P Manning Funding Availability Directly Funded Project (European/UK Students Only)...Pyruvate dehydrogenase complex (PDC) plays a key role in the regulation of cellular energetics. Decreased function of PDC results in increased metabolism of pyruvate via the lactate dehydrogenase pathway, with subsequent overproduction of lactic acid. Impaired energy generation by muscle, an increase in the lactate/pyruvate ratio in ME/CFS, and a propensity towards excess intra-muscular acidosis following limited exercise suggests PDC dysfunction in muscles of ME/CFS patients, with implications for the mechanism of expression of fatigue. ...Such sensors will include, but not be limited to, key analytes such as pyruvate, lactic acid, pH and ATP. Further, surface modification of the nanosensor will facilitate the site selective positioning of nanosensors within the cell, thus enabling organelle-directed measurements of metabolite flux in real time. ...Person Specification You should have, or expect to achieve, a first-class or upper-second-class Honours degree in a subject related to biomedical sciences
CitatFor this reason, the two charities remain committed to funding good projects using state-of-the-art MRI technologies, and encourage established research groups across the world to apply for funding.